The GLORIA study

Glucose homeostasis, metabolomics and pregnancy outcomes after bariatric surgery

The GLORIA study is an academic Belgian multicentric prospective cohort study in which we want to investigate the effects of prior sleeve gastrectomy or gastric bypass on pregnancy outcomes.

More specifically, we will study whether there are alterations in sugar metabolism and overall metabolism that play a role in the growth of the baby.

The research is coordinated by UZ Leuven with prof. dr. Katrien Benhalima as principal investigator and dr. Ellen Deleus as doctoral student. There is a collaboration with a total of 7 Belgian centers: UZ Leuven, OLV Aalst-Asse, Imelda Bonheiden, UZ Antwerpen, UZ Gent, ZNA and St-Jan Brugge.

Women who underwent obesity surgery have a lower risk of gestational diabetes or high blood pressure during pregnancy due to a healthier weight. There is also a reduced risk of high birth weight and cesarean section.

On the other hand, these babies run an increased risk of low birth weight and premature birth. We would like to further investigate the underlying causes

Knowing that patients often have abnormal sugar values after obesity surgery, we want to investigate whether this is a possible cause of growth retardation in these babies. We will therefore ask pregnant women who have a history of sleeve gastrectomy or gastric bypass, to wear a glucose sensor that continuously records subcutaneous sugar levels for several days. We want to find out whether there is a correlation between abnormal values in the mother, and the body composition and growth of the babies. In order to obtain a reliable research result, we will recruit a control pregnant woman for each participant in the study group who has a similar weight at the start of the study.